The body produces two types of endocannabinoids – anandamide and 2-AG. These are transported into the cells through the CB1 and CB2 receptors. As we age, the body becomes less efficient in producing anandamide and 2-AG. The proper functioning of the ECS also depends on the adequacy of omega-3 in the diet.Many people have experienced the feel good sensation or “high” after strenuous exercise. The lifted mood comes from the release of endorphins. Researchers now know that it is also from an increase in anandamide, which targets mainly the CB1 receptors and, to a lesser extent, the CB2 receptors.The other endocannabinoid, 2-AG, transmits signals across the brain cells and activates both CB1 and CB2 receptors. 2-AG supports brain health, immune health, as well as insulin sensitivity.Researchers have now discovered that both endocannabinoids, anandamide and 2-AG, have a considerable impact on a variety of functions including appetite, energy and balance, immunity, memory, metabolism, nervous system, sleep, and stress response. บุหรี่ไฟฟ้า
Evidence For CBD Health Benefits
The Cannabis plant contains over 100 cannabinoids. These compounds closely resemble the human endocannaboids. The main cannabinoid in hemp is CBD, and in marijuana, THC.Unlike THC, CBD does not bind directly into our cannabinoid receptors. Nevertheless, it does stimulate the activity of both CB1 and CB2 receptors without directly tapping into them. A study by the National Institute of Health found that CBD causes the body to release more endocannabinoids, especially 2-AG. Moreover, CBD inhibits the degradation of anandamide.Scientists are now beginning to discover many of CBD’s health benefits:
CBD has been touted for a wide variety of health interests, but the strongest scientific evidence is for its effectiveness in treating two rare drug-resistant childhood epilepsy conditions, namely Lennox-Gastaut syndrome (LGS) and Dravet syndrome (DS). The FDA has recently approved the first ever CBD-derived drug Epidiolex for these conditions. In numerous studies, CBD was able to reduce the number of seizures, and in some cases it was able to stop them altogether.
CBD may offer an option for treating different types of chronic pain: fibromyalgia, gout, HIV, multiple sclerosis, neuropathic, and rheumatoid arthritis. Studies found that applying CBD oil directly on the problem area helps to lower pain and inflammation. CBD works by impacting cannabinoid receptor activity in the body, reducing inflammation, and interacting with neurotransmitters.Researchers also found that subjects did not build up a tolerance to the effects of CBD, so there was no need to increase dosage continually. Unlike some pain medications, CBD is not addictive and does not have any intoxicating effects, offering much relief for people who have chronic pain.An oral spray called Sativex, which is a combination of CBD and THC, has been approved in a number of countries in Europe and Canada (but not in the U.S.) to treat pain and muscle spasms related to multiple sclerosis.Another controlled study found that Sativex significantly improved pain during movement, pain at rest, and sleep quality in people with rheumatoid arthritis.
Anxiety and Depression
Clinical trials have revealed that both marijuana and CBD may be effective in reducing different forms of anxiety including generalized anxiety disorder, panic disorder, social anxiety disorder, obsessive-compulsive disorder, and post-traumatic stress disorder (PTSD).Not only did participants in the studies felt better, they also reported reduced cognitive impairment and anxiousness. Scientists suggest that in addition to impacting the endocannabinoid system, CBD may influence receptors involved in the modulation of serotonin, a chemical messenger that plays a role in anxiety regulation.In addition, some studies showed that CBD eases depression and helps with psychotic disorders like schizophrenia. (Please note that marijuana does not help with either and may actually worsen psychosisResearchers found that cancer patients treated with CBD and THC, the psychoactive compound from marijuana, experienced significant reduction in pain. In addition, a one-to-one combination of CBD and THC administered via mouth spray reduced side effects associated with cancer treatments like nausea, vomiting, and loss of appetite.At present, more research needs to be done on whether CBD alone can produce the same beneficial outcomes.A number of cell culture studies found that cannabinoids can help slow tumor growth, reduce tumor invasion, and induce tumor cell death in various types of cancer, including brain, blood, breast, colon, pancreatic, and prostate.Scientists believe that CBD probably works by starving cancer cells of energy, making them more sensitive to the body’s immune response, and by blocking a newly discovered cannabinoid-related cancer pathway. However, human trials are needed before further conclusions can be drawn.